Adherence to Oral Therapies for Cancer

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CML Monitoring & Evaluating Response

Adherence to Oral Cancer Therapies

Impact of Poor Adherence

Factors Leading to
Low Adherence

Strategies to
Enhance Adherence

Blood Level Testing

Resistance and Loss of Efficacy

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Adherence

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Adherence to Oral Cancer Therapies

Oral therapies for cancer have created a fundamental shift in cancer care, including the recognition of cancer as a chronic disease that requires long-term treatment.¹

Multiple studies have shown that long-term oral therapies have adherence rates as low as 40%.^2-5

Oral Cancer Therapies - Patient Medication Behavior

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The Impact of Low Adherence

Factors that lead to Low Adherence

Ways to Enhance Adherence in Your Patients

Bedell CH. A changing paradigm for cancer treatment: the advent of new oral chemotherapy agents. Clin J Oncol Nurs. 2003;7(6)(suppl):5-9.
Partridge AH, Avorn J, Wang PS, Winer EP. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst. 2002;94(9):652-661.
Horwitz RI, Horwitz SM. Adherence to treatment and health outcomes. Arch Intern Med. 1993;153(16):1863-1868.
Levine AM, Richardson JL, Marks G, et al. Compliance with oral drug therapy in patients with hematologic malignancy. J Clin Oncol. 1987;5(9):1469-1476.
Lebovits AH, Strain JJ, Schleifer SJ, Tanaka JS, Bhardwaj S, Messe MR. Patient noncompliance with self-administered chemotherapy. Cancer. 1990;65(1):17-22.
Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487-497.
Urquhart J. The odds of the three nons when an aptly prescribed medicine isn't working: non-compliance, non-absorption, non-response. Br J Clin Pharmacol. 2002;54(2):212-220.